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KMID : 0370019890030000003
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Chung-Ang Journal of Pharmacal Sciences
1989 Volume.3 No. 0 p.3 ~ p.12
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Studies on Metal Chelates of Dimethyldithiocarbamic Acid
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Abstract
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Metallic ions ordinarily react with dithiocarbamic acid to give the didentate chelates.
This paper pressents the results on the copper(Ⅰ), nickel(Ⅱ), iron(Ⅲ), cobalt(Ⅱ), and bismuth(Ⅲ), metal dimethyldithiocarbamates, using the methods of spectrophotometry and thin layer chro-matography.
As far as the author know, there have been no published reports on the relation be-tween stability constants and the nature of the ligand involved.
For determination of metal-chelate composition ratio and stability constants, the method of continuous variation, introduced by Job and method based on Beer´s law have been applied.
It was found that the order of stability constants for dimethyldithiocarbamates were Cu>Ni>Co.
The author, also, presents the results on the separtaion of metal dithiocarbamates of the thin layer chromatography.
Good results were obtained on separation of metal chelates with the ratio of 5:5 and 6:4 in the mixed organic solvents such as chloroform : cyclohexane, 4:6 in pyri-dine : cyclohexane, and 3:7, 2:8. 1:9 in chloroform : benezene.
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